The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Mar. 07, 2007
Eyal Mishani, Mevasseret Zion, IL;
Samar Dissoki, Jerusalem, IL;
Galith Abourbeh, Jerusalem, IL;
Alexander Levitzki, Jerusalem, IL;
Eyal Mishani, Mevasseret Zion, IL;
Samar Dissoki, Jerusalem, IL;
Galith Abourbeh, Jerusalem, IL;
Alexander Levitzki, Jerusalem, IL;
Hadasit Medical Research Services and Development Ltd., Jerusalem, IL;
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Abstract
Novel epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors, pharmaceutical compositions including same and their use in the treatment of EGFR-TK related diseases or disorders are disclosed. Novel radiolabeled EGFR-TK inhibitors as their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are further disclosed. The disclosed EGFR-TK inhibitors comprise a polyalkylene glycol moiety and/or a hydroxy-containing moiety and are characterized by improved solubility, biostability and bioavailability. Processes of preparing the disclosed EGFR-TK inhibitors and of radiolabeling same, via, for example, one-step radiosyntheses, are also disclosed.