The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Aug. 21, 2009
Takaji Wakita, Tokyo, JP;
Takanobu Kato, Nagoya, JP;
Tomoko Date, Kawasaki, JP;
Michiko Miyamoto, Fuchu, JP;
Jun-ichi Tanabe, Kamakura, JP;
Saburo Sone, Yokohama, JP;
Takaji Wakita, Tokyo, JP;
Takanobu Kato, Nagoya, JP;
Tomoko Date, Kawasaki, JP;
Michiko Miyamoto, Fuchu, JP;
Jun-ichi Tanabe, Kamakura, JP;
Saburo Sone, Yokohama, JP;
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Toray Industries, Inc., Tokyo, JP;
Abstract
The present invention provides a method for replicating efficiently an RNA containing fulllength HCV genomic sequence and a method for producing HCV virus particles containing fulllength HCV replicon RNA or fulllength HCV genomic RNA by using a cell culture system. Further, the present invention relates to a method for producing hepatitis C virus particles which comprises culturing a cell, into which a replicon RNA comprising a nucleotide sequence comprising a fulllength genomic RNA sequence of hepatitis C virus of the genotype 2a, at least one selectable marker gene and/or at least one reporter gene and at least one IRES sequence or the fulllength genomic RNA of hepatitis C virus of the genotype 2a is introduced, and generating virus particles in the culture medium. Still further the present invention relates also to a hepatitis C vaccine and an antibody against hepatitis C virus particles.