The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Jul. 03, 2009
Shiro Shibayama, Ibaraki, JP;
Takao Yoshida, Ibaraki, JP;
Tamon Hayashi, Ibaraki, JP;
Akio Hayashi, Ibaraki, JP;
Jun Murai, Ibaraki, JP;
Shiro Shibayama, Ibaraki, JP;
Takao Yoshida, Ibaraki, JP;
Tamon Hayashi, Ibaraki, JP;
Akio Hayashi, Ibaraki, JP;
Jun Murai, Ibaraki, JP;
Ono Pharmaceutical Co., Ltd., Osaka, JP;
Medarex, Inc., Princeton, NJ (US);
Abstract
A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood, after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.