The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2013
Filed:
Feb. 17, 2010
Robert M. Krug, Austin, TX (US);
Karen Y. Twu, San Mateo, CA (US);
Rei-lin Kuo, Austin, TX (US);
Gaetano Montelione, Highland Park, NJ (US);
Edward Arnold, Belle Mead, NJ (US);
Kalyan Das, Edison, NJ (US);
Lichung MA, Plainsboro, NJ (US);
Rong Xiao, Princeton, NJ (US);
Robert M. Krug, Austin, TX (US);
Karen Y. Twu, San Mateo, CA (US);
Rei-Lin Kuo, Austin, TX (US);
Gaetano Montelione, Highland Park, NJ (US);
Edward Arnold, Belle Mead, NJ (US);
Kalyan Das, Edison, NJ (US);
LiChung Ma, Plainsboro, NJ (US);
Rong Xiao, Princeton, NJ (US);
Rutgers, The State University of New Jersery, New Brunswick, NJ (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.