The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2013
Filed:
Jul. 06, 2011
Applicants:
Xing-xian Yu, San Diego, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Brett P. Monia, Encinitas, CA (US);
Inventors:
Xing-Xian Yu, San Diego, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Brett P. Monia, Encinitas, CA (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.