The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2013
Filed:
Mar. 07, 2012
Genmin LU, Burlingame, CA (US);
David R. Phillips, San Mateo, CA (US);
Patrick Andre, San Mateo, CA (US);
Uma Sinha, San Francisco, CA (US);
Genmin Lu, Burlingame, CA (US);
David R. Phillips, San Mateo, CA (US);
Patrick Andre, San Mateo, CA (US);
Uma Sinha, San Francisco, CA (US);
Portola Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.