The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2013
Filed:
Feb. 17, 2012
Alexei Kisselev, West Lebanon, NH (US);
Dmitry V. Filippov, Leiden, NL;
Herman Overkleeft, Leiden, NL;
Alexei Kisselev, West Lebanon, NH (US);
Dmitry V. Filippov, Leiden, NL;
Herman Overkleeft, Leiden, NL;
Trustees of Dartmout College, Hanover, NH (US);
Leiden University, Leiden, NL;
Abstract
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.