The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2013
Filed:
Aug. 24, 2005
Takaji Wakita, Tokyo, JP;
Takanobu Kato, Aichi, JP;
Tomoko Date, Kanagawa, JP;
Michiko Miyamoto, Tokyo, JP;
Ralf Bartenschlager, Schriesheim, DE;
Jun-ichi Tanabe, Kanagawa, JP;
Saburo Sone, Kanagawa, JP;
Takaji Wakita, Tokyo, JP;
Takanobu Kato, Aichi, JP;
Tomoko Date, Kanagawa, JP;
Michiko Miyamoto, Tokyo, JP;
Ralf Bartenschlager, Schriesheim, DE;
Jun-ichi Tanabe, Kanagawa, JP;
Saburo Sone, Kanagawa, JP;
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Toray Industries, Inc., Tokyo, JP;
Abstract
The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5' untranslated region, a core protein coding sequence, an E1 protein coding sequence, a p7 protein coding sequence, an E2 protein coding sequence, an NS2 protein coding sequence, an NS3 protein coding sequence, an NS4A protein coding sequence, an NS4B protein coding sequence, an NS5A protein coding sequence, an NS5B protein coding sequence, and a 3′ untranslated region, and which can be autonomously replicated. In particular, the present invention relates to modified hepatitis C virus genomic RNA, which can be autonomously replicated by substitution of the RNA sequence portion encoding NS3, NS4, NS5A, and NS5B proteins of hepatitis C virus genomic RNA with a partial RNA sequence encoding NS3, NS4, NS5A, and NS5B proteins of a JFH1 strain shown in SEQ ID NO: 1.