The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Jun. 08, 2010
Ravishanker Kovi, Monroe, NJ (US);
Jayaraman Kannapan, Gujarat, IN;
Talluri Buhshaiah Chowdari, Andhra Pradesh, IN;
Chirag Vasantlal Shah, Gujarat, IN;
Ravishanker Kovi, Monroe, NJ (US);
Jayaraman Kannapan, Gujarat, IN;
Talluri Buhshaiah Chowdari, Andhra Pradesh, IN;
Chirag Vasantlal Shah, Gujarat, IN;
Apicore, LLC, Somerset, NJ (US);
Abstract
Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3')quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone.