The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Dec. 12, 2011
LI Niu, Loudonville, NY (US);
Zhen Huang, Albany, NY (US);
Hua Shi, Ithaca, NY (US);
John T. Lis, Ithaca, NY (US);
Li Niu, Loudonville, NY (US);
Zhen Huang, Albany, NY (US);
Hua Shi, Ithaca, NY (US);
John T. Lis, Ithaca, NY (US);
The Research Foundation for the State University of New York, Albany, NY (US);
Cornell University, Ithaca, NY (US);
Abstract
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.