The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Apr. 21, 2009
Zhaoning Zhu, Plainsboro, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Mihirbaran Mandal, Scotch Plains, NJ (US);
Xiaoxiang Liu, River Vale, NJ (US);
Zhaoning Zhu, Plainsboro, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Mihirbaran Mandal, Scotch Plains, NJ (US);
Xiaoxiang Liu, River Vale, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
In its many embodiments, the present invention provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R, R, R, R, R, R, R, and Rare each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.