The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Dec. 06, 2007
Francesca Boato, Tegna, CH;
Anabelle Freund, Aarau, CH;
Arin Ghasparian, Zürich, CH;
Kerstin Möhle, Wettswil, CH;
John A. Robinson, Wermatswil, CH;
Richard M. Thomas, Kew, GB;
Francesca Boato, Tegna, CH;
Anabelle Freund, Aarau, CH;
Arin Ghasparian, Zürich, CH;
Kerstin Möhle, Wettswil, CH;
John A. Robinson, Wermatswil, CH;
Richard M. Thomas, Kew, GB;
Universitaet Zuerich, Zurich, CH;
Abstract
The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.