The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Jul. 23, 2010
Kazunori Kataoka, Tokyo, JP;
Atsushi Ishii, Tokyo, JP;
Hiroyasu Takemoto, Tokyo, JP;
Masataka Nakanishi, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
Kazunori Kataoka, Tokyo, JP;
Atsushi Ishii, Tokyo, JP;
Hiroyasu Takemoto, Tokyo, JP;
Masataka Nakanishi, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
The University of Tokyo, Tokyo, JP;
Abstract
There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula:-A-B—Xwhere: A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.