The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Oct. 09, 2008
Peter Jan Leonard Mario Quaedflieg, Elsloo, NL;
Timo Nuijens, Maastricht, NL;
Claudia Cusan, Aachen, DE;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
Peter Jan Leonard Mario Quaedflieg, Elsloo, NL;
Timo Nuijens, Maastricht, NL;
Claudia Cusan, Aachen, DE;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
Enzypep B.V., Geleen, NL;
Abstract
The invention relates to a method for preparing an optionally N-protected amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester, comprising transesterifying the C-terminal t-alkyl ester of the amino acid or the C-terminal t-alkyl ester of the peptide with an alcohol (other than the t-alcohol corresponding to the t-alkyl group of the ester) in the presence of a hydrolytic enzyme (E.C. 3). The invention further relates to a method for preparing a peptide comprising coupling an activated, N-protected, amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester with an optionally C-terminal protected amino acid or an optionally C-terminal protected peptide via a peptide bond, in the presence of an enzyme catalysing peptidic bond formation.