The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2013
Filed:
Oct. 14, 2008
Bruce C. Onisko, Kensington, CA (US);
Christopher J. Silva, Albany, CA (US);
Jesus R. Requena, Briom, ES;
John Mark Carter, Richmond, CA (US);
Bruce C. Onisko, Kensington, CA (US);
Christopher J. Silva, Albany, CA (US);
Jesus R. Requena, Briom, ES;
John Mark Carter, Richmond, CA (US);
The United States of America as Represented by the Secretary of Agriculture, Washington, DC (US);
Abstract
The invention is directed to methods to distinguish among different protein conformers of the same protein such as proteins which form amyloid deposits. Using the methods of the invention, one or more protein conformers in a sample can be detected, differentiated, and quantitated. An example of a protein which is known to exist in at least two conformations is the normal prion protein (PrP) and its infectious isoform (PrP). The invention provides means to distinguish PrPfrom PrPand allows quantitation of each individually, even when the conformers are present together in a mixture. Thus, the methods of the invention can provide important tools for human and animal health.