The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2013
Filed:
Sep. 02, 2009
John E. Thompson, Waterloo, CA;
Zhong Sun, Waterloo, CA;
Catherine A. Taylor, Waterloo, CA;
Richard Dondero, Waterloo, CA (US);
Zhenyu Cheng, Waterloo, CA;
John E. Thompson, Waterloo, CA;
Zhong Sun, Waterloo, CA;
Catherine A. Taylor, Waterloo, CA;
Richard Dondero, Waterloo, CA (US);
Zhenyu Cheng, Waterloo, CA;
Senesco Technologies, Inc., Bridgewater, NJ (US);
Abstract
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide. The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.