The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2013
Filed:
Mar. 22, 2007
Ramaz Katsarava, Tbilisi, GE;
Natia Mazanashvili, Tbilisi, GE;
Zaza D. Gomurashvili, La Jolla, CA (US);
Turner Daniel Jenkins, San Diego, CA (US);
Nino Mchedlishvili, Tbilisi, GE;
Ramaz Katsarava, Tbilisi, GE;
Natia Mazanashvili, Tbilisi, GE;
Zaza D. Gomurashvili, La Jolla, CA (US);
Turner Daniel Jenkins, San Diego, CA (US);
Nino Mchedlishvili, Tbilisi, GE;
Medivas, LLC, San Diego, CA (US);
Abstract
The invention provides new aliphatic diester-di-acid-containing PEA polymer compositions with significant improvement in hydrolytic degradation rates as compared to aliphatic di-acid-containing PEA polymers. The di-acids used in the invention PEA compositions include non-toxic fatty aliphatic homologs. These molecules inherently contain two-ester groups, which easily can be cleaved by biotic (enzymatic) and abiotic hydrolysis. Additional di-acid-type compounds useful for active polycondensation are α,ω-alkylene dicarboxylates composed of short aliphatic non toxic diols and di-acids. In addition, the invention PEA polymer compositions optionally can include a second monomer, such as a C-protected L-lysine-based monomer, to introduce additional chain flexibility into the polymer. The invention PEA polymer compositions are useful for delivery of bioactive agents when administered internally.