The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2013

Filed:

Feb. 09, 2012
Applicants:

Georgette Castanedo, Redwood City, CA (US);

Irina Chuckowree, Basel, CH;

Adrian Folkes, Basel, CH;

Daniel P. Sutherlin, Burlingame, CA (US);

Nan Chi Wan, Basel, CH;

Inventors:

Georgette Castanedo, Redwood City, CA (US);

Irina Chuckowree, Basel, CH;

Adrian Folkes, Basel, CH;

Daniel P. Sutherlin, Burlingame, CA (US);

Nan Chi Wan, Basel, CH;

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/535 (2006.01); C07D 413/00 (2006.01); C07D 473/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.


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