The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2013

Filed:

Jun. 06, 2012
Applicants:

Aranapakam Mudumbai Venkatesan, Rego Park, NY (US);

Zecheng Chen, New City, NY (US);

Christoph Martin Dehnhardt, New York, NY (US);

Osvaldo Dos Santos, Astoria, NY (US);

Efren Guillermo Delos Santos, Nanuet, NY (US);

Arie Zask, New York, NY (US);

Jeroen Cunera Verheijen, Highland Mills, NY (US);

Joshua Aaron Kaplan, Nyack, NY (US);

David James Richard, Warwick, NY (US);

Semiramis Ayral-kaloustian, Tarrytown, NY (US);

Tarek Suhayl Mansour, New City, NY (US);

Ariamala Gopalsamy, Mahwah, NJ (US);

Kevin Joseph Curran, Congers, NY (US);

Mengxiao Shi, Eastchester, NY (US);

Inventors:

Aranapakam Mudumbai Venkatesan, Rego Park, NY (US);

Zecheng Chen, New City, NY (US);

Christoph Martin Dehnhardt, New York, NY (US);

Osvaldo Dos Santos, Astoria, NY (US);

Efren Guillermo Delos Santos, Nanuet, NY (US);

Arie Zask, New York, NY (US);

Jeroen Cunera Verheijen, Highland Mills, NY (US);

Joshua Aaron Kaplan, Nyack, NY (US);

David James Richard, Warwick, NY (US);

Semiramis Ayral-Kaloustian, Tarrytown, NY (US);

Tarek Suhayl Mansour, New City, NY (US);

Ariamala Gopalsamy, Mahwah, NJ (US);

Kevin Joseph Curran, Congers, NY (US);

Mengxiao Shi, Eastchester, NY (US);

Assignee:

Wyeth LLC, Madison, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/535 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of formula I wherein:Ris and R, R, and Rare defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.


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