The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2013

Filed:

Jun. 16, 2008
Applicants:

Julianne A. Hunt, Montclair, NJ (US);

Ramzi F. Sweis, Franklin Park, NJ (US);

Dooseop Kim, Westfield, NJ (US);

Florida Kallashi, Lawrence Harbor, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Inventors:

Julianne A. Hunt, Montclair, NJ (US);

Ramzi F. Sweis, Franklin Park, NJ (US);

Dooseop Kim, Westfield, NJ (US);

Florida Kallashi, Lawrence Harbor, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/553 (2006.01); A61K 31/5377 (2006.01); A61K 31/506 (2006.01); A61K 31/443 (2006.01); A61K 31/4525 (2006.01); A61K 31/423 (2006.01); A61K 31/438 (2006.01); C07D 239/42 (2006.01); C07D 267/10 (2006.01); C07D 413/14 (2006.01); C07D 401/14 (2006.01); C07D 221/20 (2006.01); C07D 211/26 (2006.01); C07D 263/57 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having the structure of Formula I1 including pharmaceutically acceptable salts of the compounds, are potent CETP (cholesterol ester transfer protein) inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis Atherosclerosis and its clinical consequences, coronary heart disease (CHD), stroke and penpheral vascular disease, represent a truly enormous burden to the health care systems of the industrialized world In formula I, A-B is an arylamide moiety.


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