The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2013
Filed:
Oct. 21, 2008
Wenjie Wang, Tokyo, JP;
Keiji Itaka, Toshima-ku, JP;
Shinsuke Ohba, Cambridge, MA (US);
Nobuhiro Nishiyama, Kita-ku, JP;
Ung-il Chung, Arakawa-ku, JP;
Yuichi Yamasaki, Bunkyo-ku, JP;
Kazunori Kataoka, Nakano-ku, JP;
Wenjie Wang, Tokyo, JP;
Keiji Itaka, Toshima-ku, JP;
Shinsuke Ohba, Cambridge, MA (US);
Nobuhiro Nishiyama, Kita-ku, JP;
Ung-il Chung, Arakawa-ku, JP;
Yuichi Yamasaki, Bunkyo-ku, JP;
Kazunori Kataoka, Nakano-ku, JP;
Transparent Inc., Chiba, JP;
Abstract
Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells. This invention, the 3D spheroid cultured construction for MSCs, leads to great improve of the differentiation efficiency. This invention relates to a cultured cell construct comprising a support; at least one island on the support; a hydrophilic and cytophobic substance applied on the surface of said support so as to encircle the island; and a spheroid which is derived from MSCs, said spheroid being in contact with the island.