The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2013
Filed:
Jun. 19, 2007
Ian Cheong, Baltimore, MD (US);
Shibin Zhou, Baltimore, MD (US);
Kenneth W. Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Ian Cheong, Baltimore, MD (US);
Shibin Zhou, Baltimore, MD (US);
Kenneth W. Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
John Hopkins University, Baltimore, MD (US);
Abstract
is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated withplus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.