The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2013
Filed:
Feb. 17, 2011
Andrès MC Allister, Genève, CH;
Maximilien Murone, Epalinges, CH;
Saumitra Sengupta, Kolkata, IN;
Shankar Jayaram Shetty, Bangalore, IN;
Andrès Mc Allister, Genève, CH;
Maximilien Murone, Epalinges, CH;
Saumitra Sengupta, Kolkata, IN;
Shankar Jayaram Shetty, Bangalore, IN;
Debiopharm S.A., Lausanne, CH;
Aurigene Discovery Technologies Ltd, Bangalore, IN;
Abstract
The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.