The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 14, 2013

Filed:

Jan. 30, 2007
Applicants:

Grace Mann, San Mateo, CA (US);

Naing Aay, San Mateo, CA (US);

Arlyn Arcalas, South San Francisco, CA (US);

S. David Brown, San Carlos, CA (US);

Wai Ki Vicky Chan, San Francisco, CA (US);

Jeff Chen, San Francisco, CA (US);

Hongwang Du, Millbrae, CA (US);

Sergey Epshteyn, Fremont, CA (US);

Timothy Patrick Forsyth, Hayward, CA (US);

Adam A. Galan, Alameda, CA (US);

Tai Phat Huynh, New York City, NY (US);

Mohamed Abdulkader Ibrahim, Mountain View, CA (US);

Henry William Beecroft Johnson, San Bruno, CA (US);

Brian Kane, Lynchburg, VA (US);

Patrick Kearney, San Francisco, CA (US);

Byung Gyu Kim, San Mateo, CA (US);

Elena S. Koltun, Foster City, CA (US);

James W. Leahy, San Leandro, CA (US);

Matthew Sangyup Lee, San Bruno, CA (US);

Gary L. Lewis, San Francisco, CA (US);

Lisa E. Meyr, Seattle, WA (US);

Robin Tammie Noguchi, San Bruno, CA (US);

Michael Pack, San Francisco, CA (US);

Brian Hugh Ridgway, Belmont, CA (US);

Xian Shi, San Bruno, CA (US);

John Woolfrey, Los Altos, CA (US);

Peiwen Zhou, Palo Alto, CA (US);

Inventors:

Grace Mann, San Mateo, CA (US);

Naing Aay, San Mateo, CA (US);

Arlyn Arcalas, South San Francisco, CA (US);

S. David Brown, San Carlos, CA (US);

Wai Ki Vicky Chan, San Francisco, CA (US);

Jeff Chen, San Francisco, CA (US);

Hongwang Du, Millbrae, CA (US);

Sergey Epshteyn, Fremont, CA (US);

Timothy Patrick Forsyth, Hayward, CA (US);

Adam A. Galan, Alameda, CA (US);

Tai Phat Huynh, New York City, NY (US);

Mohamed Abdulkader Ibrahim, Mountain View, CA (US);

Henry William Beecroft Johnson, San Bruno, CA (US);

Brian Kane, Lynchburg, VA (US);

Patrick Kearney, San Francisco, CA (US);

Byung Gyu Kim, San Mateo, CA (US);

Elena S. Koltun, Foster City, CA (US);

James W. Leahy, San Leandro, CA (US);

Matthew Sangyup Lee, San Bruno, CA (US);

Gary L. Lewis, San Francisco, CA (US);

Lisa E. Meyr, Seattle, WA (US);

Robin Tammie Noguchi, San Bruno, CA (US);

Michael Pack, San Francisco, CA (US);

Brian Hugh Ridgway, Belmont, CA (US);

Xian Shi, San Bruno, CA (US);

John Woolfrey, Los Altos, CA (US);

Peiwen Zhou, Palo Alto, CA (US);

Assignee:

Exelixis, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/535 (2006.01); C07D 239/24 (2006.01); C07D 401/10 (2006.01); C07D 413/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R, R, R, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.


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