The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2013
Filed:
Nov. 26, 2009
Junji Yodoi, Kyoto, JP;
Norihiko Kondo, Yokohama, JP;
Aoi Son, Kyoto, JP;
Noriko Kato, Ashiya, JP;
Tomijiro Hara, Higashimurayama, JP;
Tomohisa Horibe, Kyoto, JP;
Junji Yodoi, Kyoto, JP;
Norihiko Kondo, Yokohama, JP;
Aoi Son, Kyoto, JP;
Noriko Kato, Ashiya, JP;
Tomijiro Hara, Higashimurayama, JP;
Tomohisa Horibe, Kyoto, JP;
Redox Bioscience, Inc., Kyoto, JP;
Abstract
Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF. The screening method is characterized in that a test substance capable of enhancing the binding between a polypeptide belonging to the thioredoxin family and a macrophage migration inhibitory factor is selected through the steps of mixing at least one binding substance selected from the substances (1) to (4) shown below with the test substance, allowing the binding substance to bind to the macrophage migration inhibitory factor, and confirming the binding between the binding substance and the macrophage migration inhibitory factor: (1) a polypeptide belonging to the thioredoxin family; (2) a protein which comprises an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues in an amino acid sequence for a polypeptide belonging to the thioredoxin family and has the same activity as that of a polypeptide belonging to the thioredoxin family; (3) a gene encoding the polypeptide (1); and (4) a gene encoding the protein (2).