The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2013
Filed:
Aug. 14, 2009
Michael J. Birrer, Mt. Airy, MD (US);
Tomas A. Bonome, Washington, DC (US);
Anil Sood, Pearland, TX (US);
Chunhua LU, Missouri City, TX (US);
Michael J. Birrer, Mt. Airy, MD (US);
Tomas A. Bonome, Washington, DC (US);
Anil Sood, Pearland, TX (US);
Chunhua Lu, Missouri City, TX (US);
The United States of America as Represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
The University of MD Anderson Cancer Center, Houston, TX (US);
Abstract
A gene profiling signature for ovarian tumor endothelial cells is disclosed herein. The gene signature can be used to diagnosis or prognosis an ovarian tumor, identify agents to treat an ovarian tumor, to predict the metastatic potential of an ovarian tumor and to determine the effectiveness of ovarian tumor treatments. Thus, methods are provided for identifying agents that can be used to treat ovarian cancer, for determining the effectiveness of an ovarian tumor treatment, or to diagnose or prognose an ovarian tumor. Methods of treatment are also disclosed which include administering a composition that includes a specific binding agent that specifically binds to one of the disclosed ovarian endothelial cell tumor-associated molecules and inhibits ovarian tumor in the subject.