The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2013
Filed:
Jul. 14, 2005
Herman Waldmann, Oxford, GB;
Lisa K Gilliland, Oxford, GB;
Masahide Tone, Oxford, GB;
Mark R Frewin, Oxford, GB;
Louise Walsh, Cambridge, GB;
Herman Waldmann, Oxford, GB;
Lisa K Gilliland, Oxford, GB;
Masahide Tone, Oxford, GB;
Mark R Frewin, Oxford, GB;
Louise Walsh, Cambridge, GB;
Isis Innovation Limited, Oxford, GB;
Abstract
This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.