2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same

Abstract

Ester derivatives of 2-amino-2-phenyl-alkanol of general formula (I) in which: Rforms with Rand the nitrogen and carbon atoms to which they are respectively attached, a heterocycle with 4 to 7 members, optionally substituted in the α position of the nitrogen atom by one or two Rand Rradicals being able to be independently of one another hydrogen or linear or branched alkyl (1 to 4C), and Ris H or a —CO—O—CHR—OCORradical for which Ris H or linear or branched alkyl (1 to 4C), and Ris alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by the remainder of an amino acid, or represents a heterocycle, or Ris linear or branched alkyl (1 to 4C), alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, NH, alkylamino, dialkylamino optionally forming with the nitrogen atom to which they are attached, a heterocycle with 5 or 6 members, it being understood that the substituted alkyl radical is linear or branched and comprises at least 2C between >N—Rand the substituent, unless specified otherwise, alkyl or acyl are linear or branched (1 to 7C), in their R or S forms or their mixtures, as well as its pharmaceutically acceptable salts, if any.