The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Oct. 26, 2007
Applicants:
Seog Beom Song, Gyeonggi-do, KR;
IL Hwan Cho, Seoul, KR;
Yong Sik Youn, Gyeonggi-do, KR;
Dong Kwon Lim, Gyeonggi-do, KR;
Inventors:
Seog Beom Song, Gyeonggi-do, KR;
Il Hwan Cho, Seoul, KR;
Yong Sik Youn, Gyeonggi-do, KR;
Dong Kwon Lim, Gyeonggi-do, KR;
Assignee:
CJ Cheiljedang Corporation, , KR;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 211/26 (2006.01); C07D 211/28 (2006.01); C07D 213/80 (2006.01); C07D 213/803 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
Abstract
Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.