The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Sep. 02, 2008
Takeshi Ohkuma, Sapporo, JP;
Noriyoshi Arai, Sapporo, JP;
Masaya Akashi, Oiso-cho, JP;
Hirohito Oooka, Hadano, JP;
Tsutomu Inoue, Chigasaki, JP;
Takeshi Ohkuma, Sapporo, JP;
Noriyoshi Arai, Sapporo, JP;
Masaya Akashi, Oiso-cho, JP;
Hirohito Oooka, Hadano, JP;
Tsutomu Inoue, Chigasaki, JP;
Nippon Soda Co., Ltd., Tokyo, JP;
Abstract
A process is provided for efficiently producing an optically active 3-quinuclidinol derivative of high optical purity using a readily available ruthenium compound as an asymmetric reduction catalyst. This process is a process for producing an optically active 3-quinuclidinol derivative represented by the following formula (III) comprising asymmetrically hydrogenating a 3-quinuclidinone derivative represented by the following formula (I) in the presence of a ruthenium compound (II) represented by formula (II): Ru(X)(Y)(Px)[RRC*(NRR)-A-RRC*(NRR)] (in the formulas, R represents a hydrogen atom or C7 to C18 aralkyl group and the like, X and Y represent hydrogen atoms or halogen atoms and the like, Px represents a phosphine ligand, n represents 1 or 2, R1 to R8 represent hydrogen atoms or C1 to C20 alkyl groups and the like, * represents an optically active carbon atom and A represents an ethylene group and the like).