The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Jan. 28, 2009
Annika Jenmalm Jensen, Uppsala, SE;
Fredrik Lehmann, Uppsala, SE;
Erik Nordling, Danderyd, SE;
Vendela Parrow, Uppsala, SE;
Annika Jenmalm Jensen, Uppsala, SE;
Fredrik Lehmann, Uppsala, SE;
Erik Nordling, Danderyd, SE;
Vendela Parrow, Uppsala, SE;
Akinion Pharmaceuticals AB, Stockholm, SE;
Abstract
The present invention relates to compounds of the general formula (I) wherein R, Rand Rare as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). A species illustrative of members of the general formula is The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.