The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Aug. 15, 2008
Nathan Brinkman, Herscher, IL (US);
Douglas Bigler, Kankaee, IL (US);
Reinhard Bolli, Gümligen, CH;
Vreni Foertsch, Winznau, CH;
Nathan Brinkman, Herscher, IL (US);
Douglas Bigler, Kankaee, IL (US);
Reinhard Bolli, Gümligen, CH;
Vreni Foertsch, Winznau, CH;
CSL Behring GmbH, Marburg, DE;
Abstract
This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A-PI) and Apolipoprotein A-I (ApoA-I) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-I at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-I suitable for pharmaceutical use and are suitable for large-scale purification.