The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Feb. 20, 2009
John Andrew Berglund, Eugene, OR (US);
M. Bryan Warf, Eugene, OR (US);
Catherine Matthys, Eugene, OR (US);
Michael M. Haley, Eugene, OR (US);
Cameron L. Hilton, Eugene, OR (US);
John Andrew Berglund, Eugene, OR (US);
M. Bryan Warf, Eugene, OR (US);
Catherine Matthys, Eugene, OR (US);
Michael M. Haley, Eugene, OR (US);
Cameron L. Hilton, Eugene, OR (US);
Abstract
Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.