The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Jun. 12, 2008
Makoto Bamba, Tsukuba, JP;
Hidetomo Furuyama, Ashigarakami-gun, JP;
Kenji Niiyama, Tsuchiura, JP;
Toshihiro Sakamoto, Moriya, JP;
Satoshi Sunami, Toride, JP;
Keiji Takahashi, Yachiyo, JP;
Fuyuki Yamamoto, Tsukuba, JP;
Takashi Yoshizumi, Ushiku, JP;
Makoto Bamba, Tsukuba, JP;
Hidetomo Furuyama, Ashigarakami-gun, JP;
Kenji Niiyama, Tsuchiura, JP;
Toshihiro Sakamoto, Moriya, JP;
Satoshi Sunami, Toride, JP;
Keiji Takahashi, Yachiyo, JP;
Fuyuki Yamamoto, Tsukuba, JP;
Takashi Yoshizumi, Ushiku, JP;
MSD K.K., Chiyoda-Ku, Tokyo, JP;
Abstract
The invention relates to a compound of a general formula (I): wherein Aand Aeach mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; Rmeans a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; Rmeans an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of ═NH or ═O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.