The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 07, 2013

Filed:

Sep. 28, 2010
Applicants:

Josef Messinger, Sehnde, DE;

Heinrich-hubert Thole, Hannover, DE;

Bettina Husen, Hannover, DE;

Michael Weske, Burgdorf, DE;

Pasi Koskimies, Turku, FI;

Lila Pirkkala, Kaarina, FI;

Inventors:

Josef Messinger, Sehnde, DE;

Heinrich-Hubert Thole, Hannover, DE;

Bettina Husen, Hannover, DE;

Michael Weske, Burgdorf, DE;

Pasi Koskimies, Turku, FI;

Lila Pirkkala, Kaarina, FI;

Assignee:

Abbott Products GmbH, Hannover, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/566 (2006.01); A61K 31/58 (2006.01); C07J 1/00 (2006.01); C07J 17/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Substituted steroid compounds which represent selective inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulfatase, salts thereof, pharmaceutical preparations containing these compounds, and a process for the preparation of these compounds. Also disclosed is a therapeutic method of using such substituted steroid compounds, particularly in the treatment, inhibition, prophylaxis or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I and/or steroid sulfatase enzymes and/or requiring lowering of the endogenous 17β-estradiol concentration.


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