The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Oct. 09, 2009
Applicants:
Scott Sternson, Reston, VA (US);
Loren Looger, Sterling, VA (US);
Peter Lee, Reston, VA (US);
Inventors:
Assignee:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 15/12 (2006.01); C12N 15/62 (2006.01); G01N 33/567 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed.