The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Dec. 09, 2010
William J. Mcbride, Boonton, NJ (US);
Christopher A. D'souza, Pomona, NY (US);
Chien-hsing Chang, Downingtown, PA (US);
David M. Goldenberg, Mendham, NJ (US);
William J. McBride, Boonton, NJ (US);
Christopher A. D'Souza, Pomona, NY (US);
Chien-Hsing Chang, Downingtown, PA (US);
David M. Goldenberg, Mendham, NJ (US);
Immunomedics, Inc., Morris Plains, NJ (US);
Abstract
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct; b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties.