The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8431563 B1

Date of Patent:

Apr. 30, 2013

Filed:

Aug. 23, 2011

Compounds that interact with glucokinase regulatory protein for the treatment of diabetes

Applicants:

Kate Ashton, Westlake Village, CA (US);

Michael David Bartberger, Sherman Oaks, CA (US);

Yunxin BO, Thousand Oaks, CA (US);

Marian C. Bryan, West Hills, CA (US);

Michael Croghan, Thousand Oaks, CA (US);

Christopher Harold Fotsch, Thousand Oaks, CA (US);

Clarence Henderson Hale, Camarillo, CA (US);

Roxanne Kay Kunz, Santa Monica, CA (US);

Longbin Liu, Thousand Oaks, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Mark H. Norman, Thousand Oaks, CA (US);

Lewis Dale Pennington, Ventura, CA (US);

Steve Fong Poon, Woodland Hills, CA (US);

Markian Myroslaw Stec, Thousand Oaks, CA (US);

David Joseph St. Jean, Jr., Camarillo, CA (US);

Nuria A. Tamayo, Newbury Park, CA (US);

Christopher Michael Tegley, Thousand Oaks, CA (US);

Kevin Chao Yang, San Gabriel, CA (US);

Inventors:

Kate Ashton, Westlake Village, CA (US);

Michael David Bartberger, Sherman Oaks, CA (US);

Yunxin Bo, Thousand Oaks, CA (US);

Marian C. Bryan, West Hills, CA (US);

Michael Croghan, Thousand Oaks, CA (US);

Christopher Harold Fotsch, Thousand Oaks, CA (US);

Clarence Henderson Hale, Camarillo, CA (US);

Roxanne Kay Kunz, Santa Monica, CA (US);

Longbin Liu, Thousand Oaks, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Mark H. Norman, Thousand Oaks, CA (US);

Lewis Dale Pennington, Ventura, CA (US);

Steve Fong Poon, Woodland Hills, CA (US);

Markian Myroslaw Stec, Thousand Oaks, CA (US);

David Joseph St. Jean, Jr., Camarillo, CA (US);

Nuria A. Tamayo, Newbury Park, CA (US);

Christopher Michael Tegley, Thousand Oaks, CA (US);

Kevin Chao Yang, San Gabriel, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:

Todd M. Crissey

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

William Lee

Int. Cl.

CPC ...

A61K 31/497 (2006.01); A61K 31/4965 (2006.01); A61K 31/435 (2006.01); A61K 31/105 (2006.01); A61K 31/535 (2006.01); A61K 31/54 (2006.01); A61K 31/445 (2006.01); A61K 31/501 (2006.01); A61K 31/50 (2006.01); A61K 31/495 (2006.01); A61K 31/10 (2006.01); A01N 41/12 (2006.01); A01N 41/10 (2006.01); C07D 295/00 (2006.01); C07D 403/00 (2006.01); C07D 401/00 (2006.01); C07D 413/00 (2006.01); C07D 265/36 (2006.01); C07D 498/02 (2006.01); C07D 237/00 (2006.01); C07D 239/00 (2006.01); C07D 279/12 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 491/00 (2006.01); C07D 495/00 (2006.01); C07D 497/00 (2006.01); C07D 241/02 (2006.01); C07D 411/00 (2006.01); C07D 211/70 (2006.01); C07D 211/82 (2006.01); C07D 211/54 (2006.01); C07C 315/00 (2006.01); C07C 317/00 (2006.01);

U.S. Cl.

CPC ...

Abstract

The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

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