The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2013
Filed:
Jan. 07, 2008
Myung-ok Park, Seoul, KR;
Yu-kyoung OH, Seoul, KR;
Sang Myoung Noh, Seoul, KR;
Sung Sik Bang, Gyeonggi-do, KR;
Myung Suk Kim, Seoul, KR;
Myung-Ok Park, Seoul, KR;
Yu-Kyoung Oh, Seoul, KR;
Sang Myoung Noh, Seoul, KR;
Sung Sik Bang, Gyeonggi-do, KR;
Myung Suk Kim, Seoul, KR;
Engene, Inc, Vancouver, B.C., CA;
Abstract
The present invention relates to a conjugate of chitosan and polyamine polymer that is useful for transferring a desired gene medicine into cells, and a method for preparing the same. In particular, the present invention relates to a double conjugate that is prepared by 1 in king poly-L-arginine to low molecular weight chitosan or triple conjugate that is prepared by additionally linking polyethylene glycol (PEG) to the double conjugate, and a method for preparing the same. The chitosan based cationic polymer conjugate of the present invention forms a complex with negatively charged gene medicine such as plasmid DNA and small interfering RNA to efficiently transfer the desired gene medicine into cells with low cytotoxicity. Accordingly, the conjugate can be used as an effective delivery system for in vivo administration of gene medicine.