The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2013
Filed:
Mar. 02, 2010
Yu-hui Tsai, Taipei County, TW;
Li-hsuan Chiu, Taipei, TW;
Chin-chean Wong, Taipei, TW;
Wen-fu Lai, Taipei, TW;
Shih-ching Chen, Taipei, TW;
Yu-Hui Tsai, Taipei County, TW;
Li-Hsuan Chiu, Taipei, TW;
Chin-Chean Wong, Taipei, TW;
Wen-Fu Lai, Taipei, TW;
Shih-Ching Chen, Taipei, TW;
Taipei Medical University, Taipei, TW;
Abstract
The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile