The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2013
Filed:
Jan. 09, 2009
Thomas D. Reed, Arlington, VA (US);
Richard E. Peterson, Blacksburg, VA (US);
Charles C. Reed, Souderton, PA (US);
Joan Mazzarelli Sopczynski, Oreland, PA (US);
Bethany L. Merenick, Frederick, MD (US);
Jonathan Carson, Germantown, MD (US);
Catherine L. Bair, Alexandria, VA (US);
Elena Tasheva, Germantown, MD (US);
Thomas D. Reed, Arlington, VA (US);
Richard E. Peterson, Blacksburg, VA (US);
Charles C. Reed, Souderton, PA (US);
Joan Mazzarelli Sopczynski, Oreland, PA (US);
Bethany L. Merenick, Frederick, MD (US);
Jonathan Carson, Germantown, MD (US);
Catherine L. Bair, Alexandria, VA (US);
Elena Tasheva, Germantown, MD (US);
Intrexon Corporation, Blacksburg, VA (US);
Abstract
The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.