The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2013
Filed:
Jul. 31, 2009
Edwin W. Ades, Atlanta, GA (US);
Gowrisankar Rajam, Tucker, GA (US);
Sandra Steiner, Atlanta, GA (US);
George M. Carlone, Stone Mountain, GA (US);
Nikkoj Melnick, Braselton, GA (US);
Jacquelyn S. Sampson, College Park, GA (US);
Joseph E. Martinez, Morrow, GA (US);
Julie M. Skinner, Schwenksville, PA (US);
Edwin W. Ades, Atlanta, GA (US);
Gowrisankar Rajam, Tucker, GA (US);
Sandra Steiner, Atlanta, GA (US);
George M. Carlone, Stone Mountain, GA (US);
Nikkoj Melnick, Braselton, GA (US);
Jacquelyn S. Sampson, College Park, GA (US);
Joseph E. Martinez, Morrow, GA (US);
Julie M. Skinner, Schwenksville, PA (US);
Abstract
Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which includes the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present on the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administered. Compositions containing isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present of the surface of a pathogen of interest are also disclosed. In some examples, the compositions also include isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a.