The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2013
Filed:
Apr. 21, 2008
Dietrich A. Stephan, Phoenix, AZ (US);
Eric M. Reiman, Scottsdale, AZ (US);
Jennifer Webster, Pheonix, AZ (US);
Andreas Papassotiropoulos, Zurich, CH;
Pamela Heward, Mesa, AZ (US);
Dietrich A. Stephan, Phoenix, AZ (US);
Eric M. Reiman, Scottsdale, AZ (US);
Jennifer Webster, Pheonix, AZ (US);
Christopher B. Heward, late of, Mesa, AZ (US);
Andreas Papassotiropoulos, Zurich, CH;
Translational Genomics Research Institute, Phoenix, AZ (US);
Abstract
The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.