The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Apr. 17, 2009
Kook Sang Hwang, Daejeon, KR;
Soon Min Chung, Daejeon, KR;
Chang Ki Kim, Daejeon, KR;
Bok Tae Kim, Daejeon, KR;
Ju Young Lee, Daejeon, KR;
Byeong Cheol Kim, Daejeon, KR;
Goon Ho Joe, Daejeon, KR;
Kook Sang Hwang, Daejeon, KR;
Soon Min Chung, Daejeon, KR;
Chang Ki Kim, Daejeon, KR;
Bok Tae Kim, Daejeon, KR;
Ju Young Lee, Daejeon, KR;
Byeong Cheol Kim, Daejeon, KR;
Goon Ho Joe, Daejeon, KR;
LG Life Sciences Ltd., Seoul, KR;
Abstract
The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.