The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
May. 11, 2007
Carlos Enrique Lenhard, Alella Barcelona, ES;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
Carlos Enrique Lenhard, Alella Barcelona, ES;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
DSM Sinochem Pharmaceuticals Netherlands B.V., Delft, NL;
Abstract
The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising a) adding an aqueous solution of cefadroxil to a crystallization vessel and a titrant to keep a pH in the crystallization vessel of between 7 to 9; and b) lowering the pH in the crystallization vessel to a value of between 5 and 6.5 to obtain a suspension of the β-lactam compound in crystal form. The invention further relates to cefadroxil in crystal form obtainable by the process according to the present invention. The invention also relates to cefadroxil in crystal form with a CIE b value of below 12 when stored at a temperature of 25° C. for at least 1 month.