The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Jun. 30, 2008
Dennis C. Liotta, Atlanta, GA (US);
James P. Snyder, Atlanta, GA (US);
Stephen F. Traynelis, Decatur, GA (US);
Lawrence Wilson, Atlanta, GA (US);
Cara Mosley, Atlanta, GA (US);
Raymond J. Dingledine, Atlanta, GA (US);
Yesim Altas Tahirovic, Decatur, GA (US);
Scott J. Myers, Atlanta, GA (US);
Dennis C. Liotta, Atlanta, GA (US);
James P. Snyder, Atlanta, GA (US);
Stephen F. Traynelis, Decatur, GA (US);
Lawrence Wilson, Atlanta, GA (US);
Cara Mosley, Atlanta, GA (US);
Raymond J. Dingledine, Atlanta, GA (US);
Yesim Altas Tahirovic, Decatur, GA (US);
Scott J. Myers, Atlanta, GA (US);
Emory University, Atlanta, GA (US);
NeurOp, Inc., Atlanta, GA (US);
Abstract
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein:each (L)-Aris a substituted or unsubstituted, mono or bicyclic aryl or heteroaryl; W is a bond, alkyl, or alkenyl; X is a bond, NRor O and each Rand Ris independently H, alkyl, alkenyl or aralkyl or Rand Rtaken together form a 5-8 membered ring; RRare selected from certain specific substituents or a carbonyl; Y is a bond, O, S, SO, SO, CH, NH, N(alkyl), or NHC(═O); and Z is OH, NRR, NRSO(alkyl), NRC(O)NRR, NRC(O)O(alkyl), NR-dihydrothiazole, or NR-dihydroimidazole or wherein Z can fuse with Arto form selected heterocycles.