The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Apr. 08, 2008
Robert Fishman, Boston, MA (US);
Robert Havener, Lynnfield, MA (US);
Ihab Abdel Fattah, Andover, MA (US);
Anas Abdelazim, North Andover, MA (US);
Scott Newell, Ipswich, MA (US);
Tom Bishop, Wenham, MA (US);
Tamer Khayal, North Andover, MA (US);
Stanley Kyi, Andover, MA (US);
Ron Taylor, Chester, NH (US);
Doug Harriott, Melrose, MA (US);
Matthew DE Remer, Allston, MA (US);
Paul Murray, Groton, MA (US);
John Sullivan, Groton, MA (US);
Mark Anderson, Danvers, MA (US);
Richard Bringham, North Andover, MA (US);
Michael Van Driel, Mirandola, IT;
Waleed Hassanein, North Andover, MA (US);
Robert Fishman, Boston, MA (US);
Robert Havener, Lynnfield, MA (US);
Ihab Abdel Fattah, Andover, MA (US);
Anas Abdelazim, North Andover, MA (US);
Scott Newell, Ipswich, MA (US);
Tom Bishop, Wenham, MA (US);
Tamer Khayal, North Andover, MA (US);
Stanley Kyi, Andover, MA (US);
Ron Taylor, Chester, NH (US);
Doug Harriott, Melrose, MA (US);
Matthew De Remer, Allston, MA (US);
Paul Murray, Groton, MA (US);
John Sullivan, Groton, MA (US);
Mark Anderson, Danvers, MA (US);
Richard Bringham, North Andover, MA (US);
Michael Van Driel, Mirandola, IT;
Waleed Hassanein, North Andover, MA (US);
TransMedics, Inc., Andover, MA (US);
Abstract
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.