The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Oct. 08, 2008
David Gordon, Doylestown, PA (US);
Yuval Blat, Wynnewood, PA (US);
Akbar Nayeem, Newtown, PA (US);
Mark S. Kirby, New Hope, PA (US);
Bin He, Plainsboro, NJ (US);
David Gordon, Doylestown, PA (US);
Yuval Blat, Wynnewood, PA (US);
Akbar Nayeem, Newtown, PA (US);
Mark S. Kirby, New Hope, PA (US);
Bin He, Plainsboro, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1-related metabolic disorders.