The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Apr. 08, 2008
Dimitrios Zarkadas, Fanwood, NJ (US);
Vincenzo Liotta, Glen Ridge, NJ (US);
Christopher Stanley Pridgen, Union City, NJ (US);
Wing-kee Philip Cho, Princeton, NJ (US);
Zhihui Qiu, Bridgewater, NJ (US);
Dimitrios Zarkadas, Fanwood, NJ (US);
Vincenzo Liotta, Glen Ridge, NJ (US);
Christopher Stanley Pridgen, Union City, NJ (US);
Wing-Kee Philip Cho, Princeton, NJ (US);
Zhihui Qiu, Bridgewater, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.