The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Mar. 05, 2010
Jonathan Alexander Terrett, Sunnyvale, CA (US);
Heidi Leblanc, Mountain View, CA (US);
Haichun Huang, Fremont, CA (US);
Erika Meaddough, Gilroy, CA (US);
Chin Pan, Los Altos, CA (US);
Bingliang Chen, Alameda, CA (US);
Chetana Rao-naik, Walnut Creek, CA (US);
Jonathan Alexander Terrett, Sunnyvale, CA (US);
Heidi Leblanc, Mountain View, CA (US);
Haichun Huang, Fremont, CA (US);
Erika Meaddough, Gilroy, CA (US);
Chin Pan, Los Altos, CA (US);
Bingliang Chen, Alameda, CA (US);
Chetana Rao-Naik, Walnut Creek, CA (US);
Medarex, Inc., Princeton, NJ (US);
Oxford BioTherapeutics Ltd, Abingdon, GB;
Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.